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September 1977

The Metabolic Effects of Excess Noradrenaline Secretion From a Pheochromocytoma

Author Affiliations

From the Departments of Pediatrics B (Drs Passwell, Boichis, Lotan, Theodor, Cohen), Pathology (Dr David), and Urology (Dr Many), The Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel. Dr Passwell is now with The Children's Hospital Medical Center, Boston.

Am J Dis Child. 1977;131(9):1011-1014. doi:10.1001/archpedi.1977.02120220077014

• We report a 14-year-old boy with severe hypertension who was cured by surgical removal of a pheochromocytoma. The tumor was shown biochemically and morphologically to secrete predominantly noradrenaline. The metabolic effects noted in this patient were raised free fatty acid levels and depressed insulin levels, hyperreninemia, hypercalcemia, and hypercalciuria with normal parathyroid function. All these abnormalities returned to normal after removal of the tumor. It is suggested that these effects were mediated via β-adrenergic stimulation of the excess noradrenaline.

(Am J Dis Child 131:1011-1014, 1977)