November 1977

Somatomedin and Growth Hormone in the Newborn

Author Affiliations

From the Department of Pediatrics, Stanford (Calif) University School of Medicine (Dr Hintz) and the Departments of Obstetrics and Gynecology (Dr Seeds) and Pediatrics (Endocrinology Division) (Dr Johnsonbaugh), National Naval Medical Center, Bethesda, Md.

Am J Dis Child. 1977;131(11):1249-1251. doi:10.1001/archpedi.1977.02120240067013

• Somatomedin (SM) levels were measured by porcine cartilage bioassay, and growth hormone (GH) levels by radioimmunoassay in 52 full-term umbilical cord plasma samples and 28 maternal plasma samples. The SM levels in cord plasmas was 0.50 ± 0.19 units/ml (mean ± SD) compared to an adult standard plasma pool of 1.0 units/ml. The cord GH levels were 41.7 ± 36 mμg/ml. The low relative value of SM in the cord plasma is consistent with that found during early childhood, and may reflect a lower level of requirement. The high neonatal GH levels are hypothesized to be a compensatory increase to overcome factors suppressing SM production in fetal life.

(Am J Dis Child 131:1249-1251, 1977)