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November 1977

Diabetes Mellitus, Islet-Cell Antibodies, and HLA-B8 in a Patient With Systemic Lupus Erythematosus

Author Affiliations

From the Department of Pediatrics, William Beaumont Hospital, Royal Oak, Mich.

Am J Dis Child. 1977;131(11):1252-1254. doi:10.1001/archpedi.1977.02120240070014

• Evidence that autoimmune mechanisms may provide a possible explanation for the occurrence of some types of diabetes mellitus has included the clinical association of diabetes with other autoimmune conditions and the serologic demonstration of organ-specific antibodies. This article reports the case of a patient with systemic lupus erythematosus accompanied by diabetes and the presence of antibodies to pancreatic islet cells. This represents further evidence that autoimmune activity may play a role in the etiology of diabetes mellitus, which is especially interesting in light of recent HLA antigen studies that show a possible genetic link between the two diseases.

(Am J Dis Child 131:1252-1254, 1977)