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December 1977

HLA Antigens in Mucocutaneous Lymph Node Syndrome

Author Affiliations

Department of Pediatrics Kumamoto University Hospital 860 Kumamoto, Japan; Department of Pediatrics Nakanoshima Central Hospital Sapporo, Japan; Department of Pathology Asachikawa Medical College Asachikawa, Japan; Department of Pathology Hokkaido University School of Medicine Sapporo, Japan

Am J Dis Child. 1977;131(12):1417-1418. doi:10.1001/archpedi.1977.02120250099033

Kawasaki disease or mucocutaneous lymph node syndrome (MLNS), first described by Kawasaki1-2 in 1974, is an acute febrile disease of unknown etiology. Until recently, more than 6,000 cases of this disease have been listed in the survey of a special study

group supported by the Japanese Ministry of Health and Welfare. Although a number of cases have been accumulated even outside of Japan,3-6 it is much less common elsewhere.

The etiology of the disease is now under investigation including the isolation of a Rickettsia-like body.7 There is a possibility that an immunopathological mechanism similar to that of juvenile rheumatoid arthritis and infantile polyarteritis nodosa is responsible, as evidenced by cardiac involvement, increased erythrocyte sedimentation rate, positive C-reactive protein and increased α2-globulin in serum.

Several immunopathological diseases are known to be associated with individual human lymphocytes antigen (HLA),8 but to date no investigation has been

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