• A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate. Three of the seven patients were given a dosage of medication not exceeding the manufacturer's recommendation. All seven patients recovered without sequelae.
(Am J Dis Child 132:37-39, 1978)
Schwartz JF, Patterson JH. Toxic Encephalopathy Related to Antihistamine-Barbiturate Antiemetic Medication. Am J Dis Child. 1978;132(1):37-39. doi:10.1001/archpedi.1978.02120260039008