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Article
January 1978

Nephrotic Syndrome Associated With Ethosuccimide

Author Affiliations

Department of Pediatrics Beth Israel Medical Center New York, NY 10003; Mount Sinai School of Medicine New York, NY 10029; Beth Israel Medical Center New York, NY 10003

Am J Dis Child. 1978;132(1):99. doi:10.1001/archpedi.1978.02120260101027
Abstract

Ethosuccimide has been used since 1958 to treat convulsions. Three cases of lupus-like syndrome without renal involvement have been reported involving this drug.1,2,3 We describe a child in whom the nephrotic syndrome developed with hypocomplementemia, thrombocytopenia, and a positive Coombs' test in association with the administration of ethosuccimide and chlorazepate dipotassium.

Report of a Case.—A six-year-old American-born Chinese girl was hospitalized after three days of periorbital edema, anorexia, vomiting, and general malaise. She had minor motor seizures for four years and at the time of admission was receiving ethosuccimide, 1,250 mg/day for 15 months and chlorazepate dipotassium, 15 mg/day for two weeks. Three weeks prior to admission diphenylhydantoin therapy, 150 mg/day, had been discontinued after one year.

On admission vital signs were normal. She had proteinuria (4 +) (9.7 gm protein/24 hours), centrifuged urine showed six to seven WBCs, few RBCs and occasional granular casts per high powered field. Hemoglobin

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