April 1978

Inappropriate Antidiuretic Hormone Secretion in Premature Infants With Cerebral Injury

Author Affiliations

From the Department of Pediatrics, Massachusetts General Hospital, Boston.

Am J Dis Child. 1978;132(4):399-402. doi:10.1001/archpedi.1978.02120290071014

• We describe 11 premature infants with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The syndrome is far more common than the single case report in the literature would indicate. All the infants had either asphyxiation at birth, intracranial hemorrhage, or meningitis. Of the nine children available for follow-up observation, seven demonstrated serious neurological sequelae. The diagnosis of SIADH in the premature neonate may be difficult to establish due to the complexity of precipitating factors.

(Am J Dis Child 132:399-402, 1978)