October 1978

Dural Sinus Thrombosis in Leukemia

Author Affiliations

Department of Pediatrics; Department of Neurology; Department of Pathology; Department of Pediatrics 1300 University Ave University of Wisconsin Hospitals Madison, WI 53706

Am J Dis Child. 1978;132(10):1040-1041. doi:10.1001/archpedi.1978.02120350108023

Neurologic signs and symptoms in acute lymphocytic leukemia are often secondary to CNS leukemia.1 Cerebrospinal fluid pleocytosis is usually present in such cases.1 Dural sinus occlusion is a rare complication of CNS leukemia and may produce neurologic signs and symptoms without CSF pleocytosis.2 We recently evaluated a patient with acute lymphocytic leukemia in bone marrow remission. Signs and symptoms of CNS leukemia developed in this patient, without CSF pleocytosis. There was occlusion of the superior sagittal sinus and other major venous channels but no evidence of infection or CNS leukemia. This seems to be a unique occurrence.

Report of a Case.—The condition of a 6-year, 3-month-old boy was evaluated on Dec 9, 1977, for lethargy and headache. He was first seen at the University of Wisconsin Hospitals, Madison, at age 5 years for abdominal distension, fever, and drowsiness. Peripheral WBC count was 45,900/cu mm, with 60%

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