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January 1979

Disseminated Intravascular Coagulation in the Newborn

Author Affiliations

From the Division of Pediatric Hematology-Oncology, New York Hospital-Cornell Medical Center, New York. Dr Luban is now with Children's Hospital-National Medical Center, Washington, DC; Dr Miller is now with Memorial Sloan-Kettering Cancer Center, New York.

Am J Dis Child. 1979;133(1):44-46. doi:10.1001/archpedi.1979.02130010050008

• We have reviewed 53 cases of disseminated intravascular coagulation (DIC) in the newborn, including 29 cases that were confirmed at autopsy. Factors predisposing to DIC included maternal complications (60%), low Apgar scores (30%), hyaline membrane disease (62%), and sepsis (26%). Diagnostic criteria common to autopsy-proved cases included presence of fibrin degradation products, low factor V activity, a prolonged prothrombin time, and a prolonged partial thromboplastin time and/or thrombocytopenia. There appeared to be no difference in coagulation response or in mortality among patients treated with different therapeutic regimens. Survivors were older gestationally, had higher birth weights, and higher Apgar scores.

(Am J Dis Child 133:44-46, 1979)