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Article
February 1979

Penicillin-Insensitive PneumococciCase Report and Review

Author Affiliations

From the Division of Infectious Diseases, Montreal Children's Hospital, and the Department of Pediatrics, McGill University, Montreal.

Am J Dis Child. 1979;133(2):187-191. doi:10.1001/archpedi.1979.02130020079017
Abstract

• Infections due to pneumococci with decreased susceptibility (or resistance) to penicillin have been infrequently recognized. Our experience and that of others suggest that (1) penicillin susceptibility testing of significant pneumococcal isolates should become routine; (2) penicillin may not be adequate therapy for CNS infections due to pneumococci whose penicillin minimal inhibitory concentration is > 0.1 μg/ml; and (3) long-term penicillin "prophylaxis" may be inappropriate in the splenectomized patient in areas where these organisms are prevalent.

(Am J Dis Child 133:187-191, 1979)

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