• Infections due to pneumococci with decreased susceptibility (or resistance) to penicillin have been infrequently recognized. Our experience and that of others suggest that (1) penicillin susceptibility testing of significant pneumococcal isolates should become routine; (2) penicillin may not be adequate therapy for CNS infections due to pneumococci whose penicillin minimal inhibitory concentration is > 0.1 μg/ml; and (3) long-term penicillin "prophylaxis" may be inappropriate in the splenectomized patient in areas where these organisms are prevalent.
(Am J Dis Child 133:187-191, 1979)
Ahronheim GA, Reich B, Marks MI. Penicillin-Insensitive PneumococciCase Report and Review. Am J Dis Child. 1979;133(2):187-191. doi:10.1001/archpedi.1979.02130020079017