April 1979

Dientamoeba fragilisAn Intestinal Pathogen in Children?

Author Affiliations

From the Divisions of Ambulatory Pediatrics and Infectious Diseases, Department of Pediatrics (Dr Spencer), the Microbiology Section, Parasitology Division, Department of Pathology, Clinical Laboratories (Ms Garcia), and the Division of Infection Control, Department of Nursing (Ms Chapin), UCLA School of Medicine, Los Angeles.

Am J Dis Child. 1979;133(4):390-393. doi:10.1001/archpedi.1979.02130040044010

• A retrospective study was conducted of 35 children in whom Dientamoeba fragilis was the only parasite found in the gastrointestinal (GI) tract. Gastrointestinal symptoms were present in 32 (91%) of these children; diarrhea was the most common finding in patients with acute symptoms, whereas abdominal pain was more common in children with chronic symptoms. Peripheral eosinophilia was present in half of the children examined and was statistically more significant in patients with D fragilis than in a control group of children admitted for elective surgery. Therapy with diiodohydroxyquin or metronidazole was effective; children's symptoms were diminished or were eliminated on follow-up evaluation after treatment. From this association between therapy and symptomatic relief, D fragilis should be considered pathogenic in those children with GI symptoms.

(Am J Dis Child 133:390-393, 1979)