May 1979

Endocrine Abnormalities in Thalassemia MajorGertrude Costin, MD; Maurice D. Kogut, MD; Carol B. Hyman, MD; Jorge A. Ortega, MD

Author Affiliations

From the Divisions of Endocrinology and Metabolism (Drs Costin and Kogut) and Hematology-Oncology (Drs Hyman and Ortega), Children's Hospital of Los Angeles; and the Department of Pediatrics (Drs Costin, Kogut, Hyman, and Ortega), University of Southern California School of Medicine, Los Angeles.

Am J Dis Child. 1979;133(5):497-502. doi:10.1001/archpedi.1979.02130050041009

• Endocrine function evaluations in 16 patients with β-thalassemia indicate that hypogonadotropic hypogonadism, hypoparathyroidism, and reduced adrenocorticotropic hormone reserve occur frequently, whereas reduced growth hormone and thyroid reserve are less common manifestations. Hemosiderosis-induced damage of the endocrine glands seems to be the main cause for endocrine dysfunction in the patients studied.

(Am J Dis Child 133:497-502, 1979)