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August 1979

Juvenile Chronic Myelogenous Leukemia and Dermal HistiocytosisIn Von Recklinghausen's Disease

Author Affiliations

From the Departments of Pediatric Hematology/Oncology (Dr Bestak) and Pathology (Dr Mouradian), New York Hospital-Cornell Medical Center, New York; and the Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York (Dr Miller).

Am J Dis Child. 1979;133(8):831-833. doi:10.1001/archpedi.1979.02130080071014

• A 4-year-old boy with multiple café-au-lait spots and a family history of neurofibromatosis had generalized edema, histiocytic rash characterized by benign histiocytic infiltration, hepatomegaly, and life-threatening infection. Six months later, progressive splenomegaly led to juvenile chronic myelocytic leukemia that eventually proved fatal. The case represents an important association of diseases.

(Am J Dis Child 133:831-833, 1979)