• A 4-year-old boy with multiple café-au-lait spots and a family history of neurofibromatosis had generalized edema, histiocytic rash characterized by benign histiocytic infiltration, hepatomegaly, and life-threatening infection. Six months later, progressive splenomegaly led to juvenile chronic myelocytic leukemia that eventually proved fatal. The case represents an important association of diseases.
(Am J Dis Child 133:831-833, 1979)
Bestak M, Miller DR, Mouradian JS. Juvenile Chronic Myelogenous Leukemia and Dermal HistiocytosisIn Von Recklinghausen's Disease. Am J Dis Child. 1979;133(8):831–833. doi:10.1001/archpedi.1979.02130080071014