[Skip to Content]
[Skip to Content Landing]
August 1979

Congenital Glomerulosclerosis and Nephrotic Syndrome in Two InfantsSpeculations and Pathogenesis

Author Affiliations

From the Division of Nephrology, Edward Mallinkrodt Department of Dermatology, St Louis Children's Hospital (Drs Beale and Robson), and the Department of Pathology, Washington University School of Medicine, St Louis (Drs Strayer and Kissane).

Am J Dis Child. 1979;133(8):842-845. doi:10.1001/archpedi.1979.02130080082017

• The incidental finding of hyalinized glomeruli in otherwise normal infant kidneys is referred to as congenital glomerulosclerosis. Two infants had extensive glomerulosclerosis manifested by nephrotic syndrome, severe oliguria, and progressive renal failure. Both patients were believed to have had intrauterine infections. These two cases have unequivocally identified congenital glomerulosclerosis as one of the causes of nephrotic syndrome in infancy. In addition, they suggest that extensive glomerulosclerosis in some cases may be a result of congenital infections.

(Am J Dis Child 133:842-845, 1979)