February 1980

Doxepin Poisoning in a Child

Author Affiliations

Departments of Pharmacology and Pediatrics University of Kansas School of Medicine 39th at Rainbow Blvd Kansas City, KS 66103

Am J Dis Child. 1980;134(2):202-203. doi:10.1001/archpedi.1980.02130140072020

Tricyclic antidepressant drug overdose is an increasingly frequent cause of serious poisoning.1 Imipramine and amitriptyline poisonings have been more commonly reported,2-4 whereas the toxicity of doxepin, a newer drug of this class, is less well described.5 We present a case of severe doxepin hydrochloride poisoning in a child who survived and in whom the diagnosis was made in an unusual and unexpected manner. To our knowledge, no case of doxepin poisoning in a child has been previously reported.

Report of a Case.—A 4-year, 6-month-old, 13-kg girl collapsed for no apparent reason after a morning of normal activity and was taken comatose to her local physician. A grand mal seizure ensued that progressed to status epilepticus during her transfer to the University of Kansas Hospital, Kansas City. The history obtained from the parents was negative for metabolic or seizure disorders. The parents did not suspect any drug