July 1980

CSF Eosinophilia During an Acute Coxsackie B4 Viral Meningitis

Author Affiliations

Department of Pediatrics H4/434 University of Wisconsin School of Medicine 600 Highland Ave Madison, WI 53792; Department of Pediatrics Johns Hopkins University School of Medicine Baltimore, MD 21218

Am J Dis Child. 1980;134(7):703. doi:10.1001/archpedi.1980.02130190069017

Eosinophils have been present in the CSF during the course of a variety of parasitic and nonparasitic diseases.1 To our knowledge, the only viral infection associated with the presence of eosinophils in the CSF has been a chronic meningitis owing to lymphocytic choriomeningitis (LCM) virus in a 2½-year-old child.1.2 The diagnosis in the patient with LCM viral meningitis was made on the basis of serologic evidence as the virus could not be isolated. We have recently seen an acutely ill child with eosinophils in the ventricular CSF, a CSF pleocytosis, and a coxsackie B4 viral infection documented both serologically and by viral isolation.

Report of a Case.—A 13-month-old male infant was admitted after a prolonged generalized seizure that required ventilatory support. Several hours prior to admission he had a fever, cough, and vomiting. His medical history included the repair of an aortic coarctation at 2 days of