August 1980

Computerized Tomography to Define CNS Involvement in Congenital Cytomegalovirus Infection

Author Affiliations

University of Colorado School of Medicine 4200 E 9th Ave Denver, CO 80262

Am J Dis Child. 1980;134(8):795-797. doi:10.1001/archpedi.1980.02130200063020

The most serious sequelae of congenital cytomegalovirus (CMV) infection involve the CNS. However, predicting the neurological outcome of a neonate with congenital CMV may be difficult unless severe CNS damage is already obvious at birth. Some severely affected babies with intrauterine growth retardation, hepatosplenomegaly, and other stigmata associated with CMV infection have normal intellectual development without detectable neurological deficits.1 Neurological evaluation usually consists of a careful neurological examination and a roentgenogram of the skull to detect calcifications. We describe a newborn with proven congenital CMV infection who had a normal neurological examination and a normal roentgenogram of the skull; computerized tomography (CT) gave a more accurate picture of the severity of CNS involvement.

Report of a Case.—A full-term baby girl was born to a 28-year-old-mother who had a negative test for syphilis and a positive rubella titer. The baby weighted 2,110 g and had and Apgar score of 7 at