September 1980

Hyperuricemia in Cyanotic Congenital Heart Disease

Author Affiliations

Department of Pediatrics Montefiore Hospital and Medical Center Albert Einstein College of Medicine Bronx, NY 10467

Am J Dis Child. 1980;134(9):902-903. doi:10.1001/archpedi.1980.02130210078028

Sir.—The report by Dearth et al (Journal 132:900-902, 1978) called attention to the hyperuricemia that occurs with secondary polycythemia in patients with congenital cyanotic heart disease. Although the pathogenesis of the arthritis, nephropathy, and urolithiasis in primary gout appear to be related to the duration of exposure to hyperuricemia and degeee of elevation of serum urate concentration,1 the same conclusion cannot necessarily be reached in those patients with hyperuricemia that results from polycythemia secondary to cyanotic heart disease.

In an earlier publication on the natural history of 57 patients with the Eisenmenger syndrome,2 hyperuricemia (7 mg/dL to 12 mg/dL; mean, 10.5 mg/dL) was present in all of those in whom serum uric acid determinations were made, namely seven patients in the original communication and 19 obtained subsequent to publication. Despite comparably high hematocrit and serum uric acid levels, of 41 patients either first seen as adults or followed