October 1980

Immunologic Maturation in an Infant Born to a Mother With Agammaglobulinemia

Author Affiliations

From the Division of Pediatric Immunology/Allergy, Department of Pediatrics, University of California School of Medicine, Los Angeles (Drs Kobayashi and Stiehm), and the Department of Pediatrics, Loma Linda University Medical Center, Loma Linda, Calif (Dr Hyman). Dr Kobayashi is currently with the Department of Pediatrics, University of Nebraska, Omaha.

Am J Dis Child. 1980;134(10):942-944. doi:10.1001/archpedi.1980.02130220020006

• An infant born to a mother with agammaglobulinemia was followed up since birth to study immunologic maturation uninfluenced by circulating maternal antibodies. Immunoglobulin levels remained low and antibodies to immunizing antigens appeared late. These observations, together with findings in two other reported infants born to agammaglobulinemic mothers, suggest that transplacental maternal antibodies play little or no role in modulating newborn IgG production and that the delay in achieving normal levels of IgG are probably due to the immaturity of newborn B lymphocytes.

(Am J Dis Child 134:942-944, 1980)