December 1980

Fetal Damage due to Aminopterin Ingestion: Follow-up at 17½ Years of Age

Author Affiliations

Department of Pediatrics University of California Medical Center San Francisco, CA 94143

Am J Dis Child. 1980;134(12):1172-1173. doi:10.1001/archpedi.1980.02130240052015

In 1962, a female infant was delivered at 39 weeks' gestation to a mother who had attempted to induce abortion by ingesting an unknown amount of aminopterin sodium between days 55 and 58, with profound toxic effects, including epistaxis, loss of hair, and ulcerations of the mouth and skin. Failing to abort and realizing the danger of her fetus, she demanded an abortion but was refused. Her toxic symptoms subsided before delivery. The status of the child has been reported at birth, at 33 months, and at 9 years of age.1.2 This is an update on her amazing improvement at 17½ years of age.

The Patient.—At birth her weight was 1,750 g, and her appearance resembled an identically injured neonate described by Warkany et al3 who had died at 24 hours of age. Our patient was not expected to live but improved after several days. Her globular

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