March 1981

Interaction of Minoxidil and Captopril in the Treatment of Refractory Hypertension

Author Affiliations

From the Departments of Pediatrics (Drs Matson and Robillard) and Internal Medicine (Dr Norby), University of Iowa College of Medicine, Iowa City. Dr Matson is a Pharmaceutical Manufacturers Association Research Fellow. Dr Matson is now with the University of Oklahoma Health Sciences Center, Oklahoma City.

Am J Dis Child. 1981;135(3):256-258. doi:10.1001/archpedi.1981.02130270048016

• A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed. Hyperreninemic hypoaldosteronism with hyperkalemia and acidosis developed after captopril administration was started.

(Am J Dis Child 1981;135:256-258)