• Hyperpigmentation of the fingernails can occur during therapy with doxorubicin (Adriamycin). Two patterns are common: diffuse, and transversely banded. The pigment is believed to be melanin, and both patterns disappeared with discontinuation of therapy and subsequent nail growth.
(Am J Dis Child 1981;135:317-318)
Giacobetti R, Esterly NB, Morgan ER. Nail Hyperpigmentation Secondary to Therapy With Doxorubicin. Am J Dis Child. 1981;135(4):317-318. doi:10.1001/archpedi.1981.02130280007003