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Article
April 1981

Assessment of Glomerular Filtration Rate Using Single Injection of Technetium Tc 99m Pentetate

Author Affiliations

Department of Pediatrics College of Medicine Pennsylvania State University Hershey, PA 17033

Am J Dis Child. 1981;135(4):374-375. doi:10.1001/archpedi.1981.02130280064021
Abstract

In situations where complete urine collections are difficult to obtain, single-injection methods have been recommended for the assessment of glomerular filtration rates (GFRs) without recourse to urine collections.1-6 These methods have generally used millicurie doses of isotope or smaller doses and scanning equipment. This report describes the effectiveness of technetium Tc 99m pentetate at a dose of 1 to 2 μCi/kg for the assessment of GFR.

Methods.—The technetium Tc 99m pentetate was prepared from a commercial kit, diluted to 1 to 2 μCi/kg in approximately 3 mL of physiologic saline, and placed in a plastic syringe. After weighing the syringe on an analytical balance, 0.1 mL was injected into a 100-mL volumetric flask for use as a counting standard, and the syringe was reweighed. The remaining solution was injected into the subject's vein through a butterfly needle, the butterfly was flushed with 10 mL of saline, the time

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