August 1981

Leukemia and Absent Pectoralis Major: No Association?

Author Affiliations

USA; USA; Tripler Army Medical Center Honolulu

Am J Dis Child. 1981;135(8):763-765. doi:10.1001/archpedi.1981.02130320071023

Acute leukemia has been associated with the absence of the sternal portion of the pectoralis major muscle in six case reports over the past ten years. The association of this defect with ipsilateral upper-extremity anomalies is called Poland's syndrome.1 Two of three children with classic Poland's syndrome had acute lymphocytic leukemia (ALL),2-3 and one had acute myelogenous leukemia (AML).4 Three children with only isolated absent sternal pectoralis major had ALL.5-7 All patients ranged in age from 2½ through 9¾ years. We studied what is, to our knowledge, the first case of AML with the isolated anomaly. This patient was also the oldest patient displaying any of these variants with acute leukemia.

Report of a Case.—A 14-year-old boy was flown to Tripler Army Medical Center, Honolulu, on Oct 25, 1979 from Korea for evaluation of weight loss, easy fatigability, and easy bruisability. Physical examination showed large,

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