October 1981

Influence of Age and Sex on Serum Complement Components in Children

Author Affiliations

From the Department of Pediatrics, University of Minnesota Medical School, Minneapolis (Ms Roach and Drs Kim, Jerome, and Michael), and the Teenage Medical Service, Minneapolis Children's Health Center and Hospital (Dr Jerome).

Am J Dis Child. 1981;135(10):918-920. doi:10.1001/archpedi.1981.02130340030011

• Concentrations of eight complement components were determined on sera from 419 healthy children (198 boys and 221 girls) aged from 1 to 19 years. A significant correlation between concentration and age for all complement components (C1q, C1s, C4, C3, C5, factor B, properdin, and C[unk] inhibitor) was observed for girls; in the male population, a significant correlation was present only for C1q, C4, C3, C5, and properdin. The presence of a significant relationship to age suggests that this variable must be considered in establishing normal values of serum complement for children.

(Am J Dis Child 1981;135:918-920)