November 1981

Secretory Antibody Response to Respiratory Syncytial Virus Infection

Author Affiliations

From the Departments of Pediatrics (Drs Kaul, Welliver, Wong, Udwadia, Riddlesberger, and Ogra) and Microbiology (Dr Ogra), State University of New York, Buffalo, and the Division of Clinical Infectious Diseases and Virology, Children's Hospital, Buffalo (Drs Welliver, Kaul, Wong, and Ogra).

Am J Dis Child. 1981;135(11):1013-1016. doi:10.1001/archpedi.1981.02130350017007

• The secretory antibody response to primary and secondary infection with respiratory syncytial virus (RSV) in IgG, IgM, and 11S IgA immunoglobulin classes was determined using an indirect immunofluorescence antibody technique. Nasopharyngeal secretions were collected after naturally acquired primary or secondary infection with RSV. Immunoglobulin A responses to RSV were significantly greater in infants older than 6 months of age at the time of infection than in younger infants. Reinfection with RSV resulted in enhanced antibody production in all three immunoglobulin classes, and virus-specific antibody persisted for longer periods after secondary infection than after primary infection. Repeated immunizations with live RSV vaccine may be necessary for the development of immunity to severe illness.

(Am J Dis Child 1981;135:1013-1016)