November 1981

Chronic Upper Airway Obstruction and Pulmonary Hypertension in Down's Syndrome

Author Affiliations

From the Departments of Pediatrics (Drs Rowland, Nordstrom, and Burkhardt) and Radiology (Dr Bean), Baystate Medical Center, Springfield, Mass.

Am J Dis Child. 1981;135(11):1050-1052. doi:10.1001/archpedi.1981.02130350050016

• Precocious pulmonary hypertension in children with Down's syndrome may occur in patients with or without congenital heart disease. Chronic upper airway obstruction, which is common in Down's syndrome, is a well-recognized stimulus of elevated pulmonary artery pressure and may explain the propensity for idiopathic pulmonary hypertension or accelerated pulmonary vascular changes with left-to-right shunts in these children.

(Am J Dis Child 1981;135:1050-1052)