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In Reply.—We thank Dr Khuri-Bulos for pointing out the very comprehensive study that she and Dr McIntosh reported from Colorado in 1975. In that article, they reported that H influenzae disease was a known but uncommon cause of neonatal systemic disease, with reports in the literature of 17 cases between 1933 and 1973. The relatively large number of cases in our series and the series from the Colorado General Hospital indicate that this should be considered an important pathogen for neonates.
Our study was retrospective, and, to our knowledge, there have been no studies of H influenzae genital carriage at our hospital, so we cannot answer Dr Khuri-Bulos' query as to either the presence of H influenzae colonization of the mothers of these infants or the background rate of carriage in normal or pregnant women at the Yale-New Haven (Conn) Hospital.
BALTIMORE RS, EHRENKRANZ RA, WARSHAW JB, FREEDMAN RM. Neonatal Sepsis-Reply. Am J Dis Child. 1981;135(11):1080. doi:10.1001/archpedi.1981.02130350075032