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December 1981

Salmonella Sepsis in Infancy

Author Affiliations

From the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock. Dr Davis is now in private practice in Hope, Ark.

Am J Dis Child. 1981;135(12):1096-1099. doi:10.1001/archpedi.1981.02130360004003

• Of seven infants with Salmonella sepsis, three had meningitis. A review of these cases and others previously reported demonstrated that among infants less than 1 year old in Arkansas, Salmonella infection developed in 383 over a 3½-year period. The reported incidence of sepsis and/or meningitis was 1.8%; for those less than 2 months of age, it was 5.0%. Epidemiologic investigation failed to disclose a consistent source of the Salmonella colonization for young infants. Treatment of meningitis with ampicillin sodium was frequently associated with relapse or clinical failure, while chloramphenicol or a chloramphenicol-ampicillin combination appeared to offer superior efficacy. Consideration should be given to antibiotics for the routine treatment of Salmonella gastroenteritis in infants less than 3 months of age.

(Am J Dis Child 1981;135:1096-1099)