April 1982

The Intersex Child

Author Affiliations

SUNY Upstate Medical Center 750 E Adams St Syracuse, NY 13210


edited by Nathalie Josso, 273 pp, $99, Basel, Switzerland, S Karger AG, 1981.

Am J Dis Child. 1982;136(4):378. doi:10.1001/archpedi.1982.03970400096035

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This multiauthored book on the intersex child represents, in a sense, the culmination of a trend set in motion more than 30 years ago by the revolutionary experiments of Alfred Jost, and potentiated by the interaction between Jost the experimentalist and Lawson Wilkins the clinician. Their mantle has fallen on the shoulders of Nathalie Josso, editor of the present work, whose brilliant research on the anti-Müllerian hormone has ideally suited her for the organization of this publication.

The book begins with two chapters on normal sexual differentiation, the first being by Josso. She gives a profound review of the physiology of sex differentiation, which includes a two-page calendar of the chronology of sex differentiation in the human fetus. For those readers who may have some difficulty sorting out the various roles of anti-Müllerian hormone, the 5-α-reductase enzyme, and the HY antigen in fetal development, this chapter is a must.


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