May 1982

Immunological Aspects of Infection in the Fetus and Newborn: The Beecham Colloquia

Author Affiliations

Department of Pediatrics National Jewish Hospital and Research Center 3800 E Colfax Ave Denver, CO 80206


by H. P. Lambert and C. B. S. Wood, 249 pp, $39.50, London, Academic Press Inc, 1981.

Am J Dis Child. 1982;136(5):476. doi:10.1001/archpedi.1982.03970410094032

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This volume represents the proceedings of a colloquium held by the Medical Society of London in September 1979. The participants were immunologists and experts in infectious diseases, primarily from the United Kingdom but also from the United States, Kenya, and Sweden. The subjects discussed included prenatal and perinatal infections, placental protection of the fetus, maturation of immunity, mucosal-surface immunity, complement, lysozyme, lactoferrin, gastrointestinal (GI) tract immunity, immunologic components of breast milk, and prophylactic immunization of mother and newborn. The basic factual information presented in each chapter is followed by a transcript of the round table discussion that occurred after the presentation. The individual chapters vary in quality, but of particular strength are those dealing with the immunologic functions of breast milk and the role of the GI tract in preventing systemic infections. These chapters discuss cell-mediated immunity, secretory IgA, other immunoglobulins, and lactoferrin, as well as the bactericidal roles of

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