Although Kawasaki syndrome (KS) has been suspected to be caused by an infectious agent,1-4 no etiologic agent has been identified to date and epidemiologic data have demonstrated no evidence of person-to-person transmission or common exposures of patients with KS.3-5 We describe two cousins in close contact in whom KS developed within a two-week interval in April 1981. Both patients' illnesses were associated with seroconversion to parainfluenza virus type 3.
Report of Cases.—Case 1.—Five days after exposure to a sibling with an upper respiratory tract infection, a 20-month-old black boy had rhinitis and fever (temperature, 38.5 °C). On the following day, his temperature was 40 °C and a macular rash covered his chest and back; bilateral conjunctival injection, palmar erythema, and a 2 × 3-cm cervical node were noted on examination. By the fourth day of illness, swelling of his ankles, hands, and feet developed and his lips became
SCHNAAR DA, BELL DM. Kawasaki Syndrome in Two Cousins With Parainfluenza Virus Infection. Am J Dis Child. 1982;136(6):554-555. doi:10.1001/archpedi.1982.03970420078019