• We treated two patients with congenital cyanotic heart disease (CCHD) in whom associated hypertrophic osteoarthropathy (HOA) developed. Both were severely cyanotic and hypoxic for many years before HOA was fully manifested. Clinical and roentgenographic indications of bone and joint lesions disappeared completely shortly after corrective or palliative surgery. There appears to be an etiologic connection between HOA and CCHD.
(Am J Dis Child 1982;136:687-689)
Frand M, Koren G, Rubinstein Z. Reversible Hypertrophic Osteoarthropathy Associated With Cyanotic Congenital Heart Disease. Am J Dis Child. 1982;136(8):687-689. doi:10.1001/archpedi.1982.03970440031008