August 1982

Epstein-Barr Virus Antibody in Childhood Hodgkin's Disease

Author Affiliations

From the Divisions of Infectious Diseases (Drs Shope and Smith) and Hematology/Oncology (Drs Khalifa and Cushing), Children's Hospital of Michigan and the Department of Pediatrics, Wayne State University School of Medicine (Drs Shope and Cushing), Detroit. Dr Shope is now with the University of Michigan Medical Center, Ann Arbor, and Dr Khalifa is now with the Ain Shams Faculty of Medicine, Cairo.

Am J Dis Child. 1982;136(8):701-703. doi:10.1001/archpedi.1982.03970440045012

• Fifteen patients with childhood onset of Hodgkin's disease were studied for prevalence and quantity of Epstein-Barr virus (EBV) antibody to learn about the relationship between infection with EBV and Hodgkin's disease. Findings indicated that, compared with normal child control subjects, prevalence of EBV antibody is not increased in Hodgkin's disease, but the quantity of antibody increases as the duration of Hodgkin's disease increases. It seems that EBV plays no role in the cause of Hodgkin's disease and that production of greater amounts of antibody relates to immunoregulatory defects associated with Hodgkin's disease.

(Am J Dis Child 1982;136:701-703)