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August 1982

Endotracheal Administration of Epinephrine During Cardiopulmonary Resuscitation-Reply

Author Affiliations

Division of Emergency Medicine
Department of Pharmacology
Department of Emergency Medicine The Medical College of Pennsylvania 3300 Henry Ave Philadelphia, PA 19129

Am J Dis Child. 1982;136(8):753-754. doi:10.1001/archpedi.1982.03970440097034

In Reply.—The experience of Dr Lindemann is certainly a gratifying validation of our laboratory research and our clinical experiences at The Medical College of Pennsylvania, Philadelphia. Dr Lindemann's observation of endotracheal administration of epinephrine in neonates further demonstrates the usefulness of this route for emergency administration of drugs. As Dr Lindemann noted, this procedure can be invaluable not only in neonates, but in older children and adults as well. It is important to note that several other emergency drugs are efficacious when administered endotracheally.

Our most recent experience involved the use of endotracheally administered atropine sulfate.1 We could obtain normal BP and pulse rate within two minutes of administering 1.0 mg of atropine sulfate endotracheally in a patient with bradycardiac cardiovascular collapse. Following our report of successful reversal of morphine-induced respiratory depression in rabbits by the use of endotracheally administered naloxone,2 colleagues at the University of New

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