February 1983

Nephrotic Syndrome and Diffuse Mesangial Proliferative Glomerulonephritis in Children

Author Affiliations

From the Departments of Pediatrics (Drs Garin, Geary, and Richard) and Pathology (Dr Donnelly), University of Florida College of Medicine, Gainesville.

Am J Dis Child. 1983;137(2):109-113. doi:10.1001/archpedi.1983.02140280007003

• The clinical course, response to therapy, and outcome were analyzed in 25 children with nephrotic syndrome associated with moderate to severe mesangial cell proliferation. The conditions of more than two thirds of the patients (16/23) failed to respond to prednisone therapy, and renal insufficiency or failure developed in 13. Our data suggest an association between response to therapy and degree of mesangial cell proliferation. Persistent nephrotic syndrome was associated with slow deterioration of renal function.

(Am J Dis Child 1983;137:109-113)