February 1983

Retinoblastoma in Navajo Indian Children

Author Affiliations

From the Department of Pediatrics, Gallup (NM) Indian Medical Center, Public Health Service, Indian Health Service. Dr Berkow is now with the Indiana University School of Medicine, Indianapolis, and is a clinical fellow of the American Cancer Society.

Am J Dis Child. 1983;137(2):137-138. doi:10.1001/archpedi.1983.02140280035009

• Retinoblastoma occurs with an observed incidence of one in 18,000 live births, and 35% to 45% of cases are transmitted genetically in a dominant fashion. A retrospective analysis of Navajo Indian children during the past 15 years disclosed an incidence 2½ to three times the expected. This observation raises the possibility that silent expression of the gene for retinoblastoma occurs more frequently among the Navajo population compared with the population at large.

(Am J Dis Child 1983;137:137-138)