• Assays for cytotoxin of Clostridium difficile were performed on stool samples submitted to the laboratory for routine microbiologic study. Cytotoxin was recovered from 8.6% of 208 pediatric patients studied. Cytotoxin was identified significantly more often in younger patients (median age, 11 months) and in those with hospital-associated illness (17%) and antibiotic-associated illness (18%). Hospitalization and antibiotic use were significant independent risk factors. Clinical diagnoses in patients with C difficile cytotoxin included classic pseudomembranous colitis, acute self-resolving diarrheal syndrome, chronic diarrhea with failure to thrive, infant botulism, and asymptomatic carriage.
(Am J Dis Child 1983;137:271-274)
Thompson CM, Gilligan PH, Fisher MC, Long SS. Clostridium difficile Cytotoxin in a Pediatric Population. Am J Dis Child. 1983;137(3):271-274. doi:10.1001/archpedi.1983.02140290057015