April 1983

Evidence of Non-A, Non-B Hepatitis in Children With Acute Leukemia and Chronic Liver Disease

Author Affiliations

From the Cattedra di Puericultura, Università di Milano, Italy (Drs Locasciulli, Uderzo, and Masera), the Istituto di Medicina Clinica-Patologia Medica, Università di Padova, Italy (Drs Alberti, Barbieri, and Realdi), and the Department of Medicine, Liver Unit, King's College Hospital and Medical School, London (Dr Portmann).

Am J Dis Child. 1983;137(4):354-356. doi:10.1001/archpedi.1983.02140300036010

• Eleven children with acute lymphoblastic leukemia and chronic liver disease, who had negative reactions for hepatitis B virus markers in the liver, were studied at the time of therapy withdrawal for an antigen-antibody system linked to non-A, non-B (NANB) hepatitis infection. By immunofluorescence, six of the 11 children had a positive reaction for the NANB antigen in the liver, and five of these six children also had a positive reaction for the NANB antibody in serum. Histologic lesions were more severe in patients with the NANB antigen in the liver compared with those with a negative reaction.

(Am J Dis Child 1983;137:354-356)