• Seventeen children with severe pain due to malignant neoplasm were successfully treated with a subcutaneous infusion of morphine sulfate using a syringe pump. Pain relief was adequate in every case without major side effects. The median dosage required was 0.06 mg/kg/hr (range, 0.025 to 1.79 mg/kg/hr). Three patients received the subcutaneous infusion at home. No patient required an intravenous line for pain control.
(Am J Dis Child 1983;137:383-385)
Miser AW, Davis DM, Hughes CS, Mulne AF, Miser JS. Continuous Subcutaneous Infusion of Morphine in Children With Cancer. Am J Dis Child. 1983;137(4):383–385. doi:10.1001/archpedi.1983.02140300061017