April 1983

Continuous Subcutaneous Infusion of Morphine in Children With Cancer

Author Affiliations

From the Division of Hematology-Oncology, Department of Pediatrics, Ohio State University, Columbus (Drs A. Miser, Mulne, and J. Miser), and Columbus Children's Hospital (Mss Davis and Hughes). Dr A. Miser is now with the Pediatric Oncology Branch, National Cancer Institute, Bethesda, Md.

Am J Dis Child. 1983;137(4):383-385. doi:10.1001/archpedi.1983.02140300061017

• Seventeen children with severe pain due to malignant neoplasm were successfully treated with a subcutaneous infusion of morphine sulfate using a syringe pump. Pain relief was adequate in every case without major side effects. The median dosage required was 0.06 mg/kg/hr (range, 0.025 to 1.79 mg/kg/hr). Three patients received the subcutaneous infusion at home. No patient required an intravenous line for pain control.

(Am J Dis Child 1983;137:383-385)