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January 1984

Vancomycin Dosage in Pediatrics Reconsidered

Author Affiliations

From the Division of Infectious Diseases (Drs Alpert, Preblud, and Plotkin) and the Microbiology Laboratory (Dr Campos), The Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania, Philadelphia (Dr Harris).

Am J Dis Child. 1984;138(1):20-22. doi:10.1001/archpedi.1984.02140390012005

• Vancomycin hydrochloride levels were studied in 44 children (age range, 10 days to 10 years). These children received doses of vancomycin within current recommendations. Major variations in vancomycin levels were demonstrated in similar age groups and dosage regimens. For patients in the first month of life, second month of life, and older ages, respectively, 70%, 39%, and 30% of the peak determinations and 53%, 50%, and 23% of the trough determinations were greater than the desired level. Potentially toxic levels were found in eight patients.

(AJDC 1984;138:20-22)