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April 1984

Increasing Ampicillin-Resistance Rates in Hemophilus influenzae Meningitis

Author Affiliations

From the Field Services Division, Epidemiology Program Office, Centers for Disease Control, assigned to Colorado Department of Health, Denver (Dr Istre); the Communicable Disease Control Section, Colorado Department of Health, Denver (Ms Conner and Dr Hopkins); and the Division of Pediatric Infectious Diseases, Denver Children's Hospital (Dr Glode). Dr Istre is now with the Epidemiology Section, Oklahoma Department of Health, Oklahoma City.

Am J Dis Child. 1984;138(4):366-369. doi:10.1001/archpedi.1984.02140420032012

• We studied the epidemiology of reported Hemophilus influenzae meningitis in Colorado for the years 1977 through 1981. Of 340 culture-confirmed cases, 94% occurred in children less than 5 years old. A marked seasonal variation was present, with peaks in late fall—early winter and late spring. The percentage of H influenzae isolates resistant to ampicillin increased from 4.2% in 1977 to 31.3% in 1981. The incidence of reported disease in children younger than 5 years of age increased from 26 per 100,000 population in 1977 to 39 per 100,000 population in 1981. The overall case fatality rate was 5.2%; mortality was somewhat higher for persons with ampicillin-resistant infections (9.4%) than for those with ampicillin-sensitive infections (4.3%). Our results agree with previous reports of an increasing rate of ampicillin resistance in H influenzae meningitis and indicate a possible increasing incidence of this disease in Colorado.

(AJDC 1984;138:366-369)