May 1984

Aminophylline Reduces Cerebral Blood Flow Velocity in Low-Birth-Weight Infants

Author Affiliations

From the Department of Pediatrics, Women and Infants Hospital of Rhode Island, and the Section of Pediatrics, Brown University Program in Medicine, Providence. Dr Rosenkrantz is now with the University of Connecticut Health Center, Farmington.

Am J Dis Child. 1984;138(5):489-491. doi:10.1001/archpedi.1984.02140430065017

• Cerebral blood flow decreases substantially in the adult after a single bolus injection of aminophylline. To determine if the cerebral circulation of the low-birth-weight infant behaves in a similar manner, we measured cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of nine infants treated with an intravenous bolus dose of 5 mg/kg of body weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at 60 and 120 minutes following the aminophylline administration. There was a concurrent substantial reduction in Pco2 from 45±7 to 39±7 mm Hg before and 120 minutes after the aminophylline administration, respectively. The reduction in CBFV may be the result of a reduction in Pco2 resulting from aminophylline treatment.

(AJDC 1984;138:489-491)