May 1984

Drug Treatment of Recurrent Febrile Seizures

Author Affiliations

Anderson Pediatric Group 705 N Fant St Anderson, SC 29621

Am J Dis Child. 1984;138(5):507. doi:10.1001/archpedi.1984.02140430083025

Sir.—I read with interest the article by Antony and Hawke1 in which they compared phenobarbital sodium with carbamazepine in the prevention of recurrent febrile convulsions.

Several years ago, I also ran a double-blind study in which I treated one group of children with phenobarbital and another group with an antacid (Maalox Plus) with sodium bicarbonate. The children were not given antipyretic therapy. At the time, I had been told by a neurologist that he believed that metabolic acidosis was responsible for the febrile seizures occurring in the children. After being told this, I embarked on a positive program to reassure the parents of the antacid-treated children of this fact, as I had reassured the parents of the phenobarbital-treated children. Much to my surprise, the children who received the antacid with a half teaspoon of sodium bicarbonate had no further febrile seizures, with the exception of one child, who