• Hypertension, severe headache, and grand mal seizures developed in a 13-year-old girl after ingestion of one nonprescription diet pill containing phenylpropanolamine and caffeine. This case is at least the sixth report of seizures with phenylpropanolamine use in children or adolescents. Phenylpropanolamine ingestion must be included in the differential diagnosis of young patients, particularly adolescents, in whom acute neurological symptoms develop.
Bale JF, Fountain MT, Shaddy R. Phenylpropanolamine-Associated CNS Complications in Children and Adolescents. Am J Dis Child. 1984;138(7):683-685. doi:10.1001/archpedi.1984.02140450065020