August 1984

Use of Sodium Chromate Cr 51 in Diagnosing Childhood Idiopathic Pulmonary Hemosiderosis

Author Affiliations

From the Departments of Pediatrics (Drs Kurzweil and Dr Miller), Medicine (Mr Freeman and Dr Mayer), and Medical Physics (Mr Reiman), Memorial Sloan-Kettering Cancer Center, New York.

Am J Dis Child. 1984;138(8):746-748. doi:10.1001/archpedi.1984.02140460038012

• The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr 51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in equivocal cases.

(AJDC 1984;138:746-748)