Sir.—We read with interest the report by Hauser et al1 on 30 children with common variable hypogammaglobulinemia (CVHG). One of them died of chronic active hepatitis (CAH) due to hepatitis B virus (HBV) infection.
Liver disease is uncommon in children with primary hypogammaglobulinemia,2 but CAH related to HBV infection already has been described in young adults.3 We report the case of a young boy with CVHG who manifested an HBV-negative hepatitis and was successfully treated with steroids.
Report of a Case.—A 9-year-old boy had been apparently well until 3 years of age, when the onset of various bacterial infections (pneumonia with pleural effusion, acute otitis media, and pericarditis) together with the finding of panhypogammaglobulinemia and normal peripheral blood B lymphocytes led to the diagnosis of CVHG. He was then treated with intramuscular γ-globulin replacement, periodic cycles of antibiotics, and chest physiotherapy. From the age of
MAGGIORE G, DE GIACOMO C, RASCIO N, MARSEGLIA G, DUSE M, UGAZIO AG. Severe Hepatitis B Virus—Negative Chronic Hepatitis Responsive to Steroids in a Child With Common Variable Hypogammaglobulinemia. Am J Dis Child. 1984;138(8):796. doi:10.1001/archpedi.1984.02140460086033