October 1984

Purpura Fulminans Following Late-Onset Group B β-Hemolytic Streptococcal Sepsis

Author Affiliations

From the Department of Pediatrics (Dr Isaacman), Divisions of Neonatology (Dr Heroman) and Hematology-Oncology (Dr Lightsey) and the Clinical Investigation Department, Naval Hospital, San Diego.

Am J Dis Child. 1984;138(10):915-916. doi:10.1001/archpedi.1984.02140480017006

• A 16-day-old male infant initially was in septic shock. Following intensive resuscitation, thrombohemorrhagic lesions developed over his extremities, except for the limb with an arterial line maintained by a continuous heparin sodium infusion. Blood and CSF cultures yielded group B β-hemolytic streptococci. Results of laboratory studies and clinical appearance supported the diagnosis of purpura fulminans (PF). Systemic heparinization was therefore started, and subsequently his condition improved. Because of the distinct difference in limb sparing, we concluded heparin has a beneficial effect on the evolution of PF.

(AJDC 1984;138:915-916)