• A 31-month-old girl required constant intravenous (IV) infusion of naloxone hydrochloride to treat codeineinduced respiratory and CNS depression. The infusion rate was 0.4 mg/hr (27 μg/kg/hr) over nine hours, without apparent side effects or evidence of toxic effects, for a total naloxone hydrochloride dose of 4.1 mg (280 μg/kg). Constant naloxone hydrochloride infusion at an initial rate of 0.4 mg/hr in pediatric narcotic poisoning should be considered if the patient responds inadequately to an initial 0.01-mg/kg bolus, requires repeated administration to reverse narcotic-induced effects, or has ingested long-acting agents. Continuous IV naloxone infusion is a convenient, safe, and effective method to treat narcotic overdose.
Lewis JM, Klein-Schwartz W, Benson BE, Oderda GM, Takai S. Continuous Naloxone Infusion in Pediatric Narcotic Overdose. Am J Dis Child. 1984;138(10):944-946. doi:10.1001/archpedi.1984.02140480046014