December 1984

Prolonged Elevation of Transaminase Concentration in Children With Unsuspected Myopathy

Author Affiliations

From the Departments of Pediatrics (Drs Schwarz and Burris) and Pathology (Dr deMello), St Louis University School of Medicine, Cardinal Glennon Memorial Hospital for Children; the Department of Pediatrics, Hartford (Conn) Hospital and the University of Connecticut Health Center (Dr Hyams); and the Departments of Pediatrics (Drs Biller and Maksimak) and Medicine (Dr Winter), Harvard Medical School, Children's Hospital Medical Center, and the Department of Pediatrics, Tufts University School of Medicine, New England Medical Center (Dr Grand), Boston.

Am J Dis Child. 1984;138(12):1121-1124. doi:10.1001/archpedi.1984.02140500027009

• Prolonged elevation of the serum transaminase concentration in an asymptomatic child is usually thought to be secondary to liver disease. Four children with unexplained persistent elevation of serum transaminase concentration were referred to a pediatric gastroenterologist for studies of liver disease. Subsequent evaluation disclosed abnormal muscle biopsy findings in all four patients. This experience suggests that an appropriate workup for occult myopathy is indicated in such patients before invasive diagnostic procedures for evaluation of liver disease are undertaken.

(AJDC 1984;138:1121-1124)